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Elaine Hinzey is a registered dietitian, writer, and fact-checker with nearly two decades of experience in educating clients and other healthcare professionals.
A "drug class" is a group of medications with certain similarities. Three dominant methods are used to classify them:
This article walks you through how classification works, why it's necessary, and the types of classification.
Not all drugs fit neatly into a single category. Some drugs are grouped together under one method but not another.
Others belong in multiple classes even within the same system. An example is finasteride, which treats enlarged prostate and regrows hair. So it’s in two categories based on those uses.
Outside of classifications, you have drugs used off-label (for non-approved reasons). A prime example is levothyroxine. It’s approved for hypothyroidism (low thyroid function). But it’s often used off-label to treat depression.
It can be confusing when you see a drug called an ACE inhibitor, an antihypertensive, and a vasoconstrictor. But all these terms describe the same drug used for the same purpose.
Newer and more advanced drugs are introduced into the market each year. That includes:
Classifications will likely become even more diverse and distinct because of them. This reflects the ever-expanding knowledge about human biochemistry.
Drugs are classified by how they work, what they treat, and their chemical structure. Some drugs fit in more than one category. Others are grouped together under some classification methods but not others.
The aim of drug classification is to make sure you use a drug safely and get the greatest possible benefit. Every time you take a drug, your body chemistry changes.
Medications are meant to help. But they sometimes cause harmful side effects. If you take multiple drugs, they may change each others' effectiveness. They can also make side effects more severe.
By noting the class of a drug, you and your healthcare team can understand what to expect from it. That includes the risks and which others drugs you can switch to.
Classification also helps identify drug-drug interactions and the potential for drug resistance.
The action of one drug can make another drug less effective. They may change the way your body absorbs or uses the drug.
When classified by mechanism of action, an interaction that affects one drug will usually affect others in the same class.
For example, antacids work by blocking stomach acid. But they also deplete stomach acids you need to break down protease inhibitors (a class of HIV drugs). Taking these drugs together makes the HIV drug less able to control the infection.
Organ Systems
It's important to use caution when combining drugs that affect the same organ system.
Your liver uses an enzyme called CYP3A4 to process drugs out of your system. If you take two drugs metabolized by it, your liver may not be able to clear them effectively. They can build up, leading to toxicity (overdose).
By classifying a drug by its CYP3A4 action, healthcare providers can better avoid this interaction.
The same applies to drugs like methotrexate and Advil (ibuprofen) that are metabolized by the kidneys. Taking them together can lead to toxicity and even kidney failure.
Doubling Up
Sometimes, combining drugs makes them too effective.
For instance, non-steroidal anti-inflammatory drugs (NSAIDs) like ibupfofen or aspirin increase your bleeding risk. Anticoagulants (blood thinners) like Coumadin (warfarin) keep your blood from clotting. Taking them together can lead to dangerous excessive bleeding.
It's often dangerous to take two drugs from the same class, such as two NSAIDs. Doubling up often doubles the risk or severity of side effects.
Drugs are classified for safety and effectiveness reasons. It helps limit side effects, predict your response to it, and choose a replacement drug when one doesn't work. You shouldn't take multiple drugs from a single class or that affect the same organ system. Some classes of drugs shouldn't be used together.
Medications for chronic infections work in a specific way. If used incorrectly or for a long time, the infection can become resistant to it. That means the drug won't work as well. Other drugs of the same class may also be ineffective.
Antibiotics come in nine major classes. HIV drugs come in six classes. Some classes are more likely to lead to resistance. Healthcare providers often prescribe drugs from multiple classes to get the best possible control of the infection.
"Treatment staging" means starting with the mildest possible drugs. You then work up until you find what's effective. That's because milder drugs have fewer side effects.
This often means first taking over-the-counter (OTC) drugs. If they're not effective, you may move up to a prescription drug.
Guidelines for healthcare providers often list "preferred" classes and "alternate" classes for when the preferred ones don't work.
With severe pain, for example, staging generally goes:
Drug staging is also vital to treating chronic diseases such as:
In cases like these, you may start with one drug class and work your way up to other classes.
Using antibiotics from different classes can help prevent infectious agents from becoming resistant to them.
Treatment staging means starting with the mildest, safest drugs and moving up in strength until you find the right level. Typically, you'll move up within the same class.
The thousands of drug classes and subclasses can be classified in several ways.
In 1976, the World Health Organization (WHO) created a system called the Anatomical Therapeutic Chemical (ATC) Classification System. It categorizes a drug based on five levels.
For each level, either a letter or numbers are assigned.
This system is meant for healthcare providers and isn't useful to you. But the strict hierarchy it establishes protects you from drug errors (like getting the wrong one.)
A non-profit, non-governmental organization called the United States Pharmacopeia (USP) was established in 1820. Its goal is to ensure prescription and OTC drugs approved in the U.S. meet quality standards.
Those that do go on the National Formulary issued by the U.S. Food and Drug Administration (FDA).
Among its many functions, the USP was tasked by the U.S. Congress to classify drugs. It helps guide healthcare providers when it comes to prescribing drugs under the Medicare Prescription Drug Benefit.
Worldwide, 34 other countries have national pharmacopeias. The European Union Pharmacopeia serves EU countries without their own. Most other countries rely on the International Pharmacopeia maintained by the WHO.
The USP classifies drugs in a far broader way than the ACT system. It categorizes them by:
From the broadest perspective, you're left with 51 drug classes and thousands of sub-classes and sub-categories.
Drug classifications are important. They help protect you from severe side effects and drug interactions. They help ensure your body can break down and use the medication. They help guide many treatment decisions.
The main classification systems are ATC and USP. They use different methods but both are useful tools.
Your healthcare provider(s) should be aware of everything you're taking so they can ensure you're not mixing drugs that don't mix well or doubling up on one class. Your pharmacist can help with this, too.
But being aware of what classes your medications are in can help prevent mistakes by healthcare workers or by you when you choose OTC products. When in doubt, ask a provider or pharmacist if something is safe—before you take it.
Drug therapy is using any substance that's not food in order to prevent, diagnose, or treat a disease or condition. Anything that changes your body chemistry is considered a drug, including natural products.
People respond differently to drugs for many reasons. It could be due to:
This is why you should never take medication prescribed for someone else.
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U.S. Food and Drug Administration. Pharmacologic class. Updated March 27, 2018.
National Institutes of Health, U.S. National Library of Medicine: MedlinePlus. Finasteride. Updated January 15, 2018.
Bauer M, Berman S, Stamm T, et al. Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study. Mol Psychiatry. 2016;21(2):229–236. doi:10.1038/mp.2014.186
Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230. Published 2017 Oct 10. doi:10.1186/s12877-017-0621-2
U.S. Food and Drug Administration. Drug interactions: what you should know. Updated September 25, 2013.
Nawas GT, Phan TT. OTCs can interact with antiretrovirals: Here's what you need to know. Pharmacy Today. 2018;24(9).
U.S. Food and Drug Administration. Drug development and drug interactions: table of substrates, inhibitors, and inducers. Updated March 10, 2020.
Svanström H, Lund M, Melbye M, Pasternak B. Concomitant use of low-dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritis. Pharmacoepidemiol Drug Saf. 2018;27(8):885–893. doi:10.1002/pds.4555
Choi KH, Kim AJ, Son IJ, et al. Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting. J Korean Med Sci. 2010;25(3):337–341. doi:10.3346/jkms.2010.25.3.337
Centers for Disease Control and Prevention. Antibiotic resistance patient safety atlas: Outpatient antibiotic prescription data.
NAM Aidsmap. Types of antiretroviral medications. Updated May 2021.
Kaiser Family Foundation. Management and delivery of the Medicaid pharmacy benefit. Updated December 6, 2019.
World Health Organization Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment. Updated 2011.
P&T Community. United States Pharmacopeia celebrates 200 years of building trust in medicines, supplements and foods. Updated January 6, 2020.
World Health Organization. International meeting of world pharmacopoeias. Updated March 2013.
United States Pharmacopoeia. USP Medicare model guidelines v. 7.0.
National Institutes of Health, National Cancer Institute. Drug therapy.
University of Connecticut: UConn Today. Why prescription drugs can work differently for different people. Updated October 13, 2021
The United States Pharmacopeial Convention Inc. USP drug classification 2021 (USP DC 2021). PDF available for download.
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